Endocrine Abstracts

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive age women and predispose to the development of metabolic disturbances. However, Rotterdam criteria, commonly used to diagnose and classify this disorder, do not include metabolic markers. Recent research has shown that several metabolic factors may play a role in PCOS pathogenesis. Branched-chain amino acids (BCAA) are the group of essential amino acids including leucine, isol...

Background: Polycystic ovary syndrome (PCOS), the commonest endocrinopathy of women in the reproductive age is often accompanied by insulin resistance (IR). The aim of the study was to assess the prevalence of IR in women diagnosed with PCOS, where IR was assessed by methods most commonly used in clinical practice, i.e. homeostatic model assessment (HOMA) and insulin resistance index (IRI), also known as the Belfiore index.Patients and methods: The study...

Introduction: Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. It occurs in Europe with an incidence of 1:3000–1:4000.Thyroid dysgenesis – agenesis, hypoplasia or ectopy – is responsible for 80–90% of CH cases. An ectopic thyroid gland is an uncommon inborn anomaly and is typically located along the thyroglossal duct. To date only few cases of CH due to lingual thyroid diagnosed in adulthood were reported in the literature.</...

Introduction: Polycystic ovary syndrome (PCOS) patients present with or without biochemical hyperandrogenism (HAPCOS or non-HAPCOS, respectively). Although cardiometabolic and hormonal abnormalities have been reported in women with PCOS, particularly those with hypertension, direct comparisons between normotensive (blood pressure (BP) <140/90 mmHg) patients with HAPCOS and non-HAPCOS are scarce. Data on N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) in PCO...

Introduction: Adropin, a newly discovered peptide hormone, seems to have broad implications in energy homeostasis and metabolism in humans. Its main role is in maintaining appropriate carbohydrate and lipid economy. However, the aim of this study was to look at the novel role of adropin as a potential marker for cardiac function and nutrition status in hemodialyzed (HD) patients. To the best of our knowledge, this was the first study to consider the relationship between serum ...

Introduction: Chronic exposure to glucocorticoid excess, either endogenous or exogenous, is associated with a hypercoagulable state and a high thromboembolism risk. The underlying mechanism of this phenomenon is still unclear. Clinical studies have indicated various abnormalities of procoagulant, anti-coagulant and fibrynolytic factors, e.g.: alterations of clotting factors (F), plasminogen activator inhibitor (PAI-1), plasminogen, antithrombin. Moreover, other consequences of...

Objective: Vitamin D has a pleiotropic effect on the human body. Besides its classical function as a regulator of calcium and phosphorus metabolism, it influences the secretion of other hormones, modulates the immune response and regulates cell proliferation and differentiation. Because women in twin pregnancies have higher metabolic needs, it can be expected that they might have higher risk of vitamin D deficiency.Aim of the study and method: The aim is...

Background: A significant body of research indicates that transgender and gender-nonconforming persons represent an underserved population susceptible to health care disparities. The attitudes and knowledge of medical doctors toward transgender people have important implications for the future quality of healthcare for transgender patients.Specific Aim: The aim of this study was an assessment of coverage of transgender care issues in training curricula o...

Introduction: Graves’ disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. We have recently demonstrated novel, previously not reported association between a presence of alleles HLA-B*39:06, -B*37:01, -C*14:02, -C*03:02, -C*17:01, -DRB1*14:01 and GD. These alleles are independent risk factors, with no linkage disequilibrium with other,...

Introduction: Subacute thyroiditis is a thyroid inflammatory disease, triggered mainly by viral factors in genetically susceptible individuals. Up to 2020, only HLA-B*35 was confirmed as SAT-related. However, obviously in HLA-B*35-negative patients, some other genetic background occurs. Material and Methods: We performed HLA-typing using high resolution NGS method in different groups of patients with SAT and demonstrated the new association between HLA a...